Publications

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*equal contribution; #corresponding autors 

 

2025

Prolonged mitosis: A key indicator for detecting stressed and damaged cells

Sparr C, Meitinger F.

Current Opinion in Cell Biology. 2024 Dec 24;92:102449. doi: 10.1016/j.ceb.2024.102449.

 

Genetic engineering and screening using base editing and inducible gene knockout

Ng EFY, Meitinger F.

Methods in Molecular Biology. 2025;2872:167-187. doi: 10.1007/978-1-0716-4224-5_12.

 

2024

Control of cell proliferation by memories of mitosis

Meitinger F#, Belal H, Davis RL, Martinez MB, Shiau AK, Oegema K#, Desai A#.

Science. 2024 Mar 29;383(6690):1441-1448. doi: 10.1126/science.add9528. Epub 2024 Mar 28.

Highlighted in Bertolin AG, Gottifredi V. A mitotic stopwatch determines cell fate. Science. 2024 Mar 29;383(6690):1414-1415. doi: 10.1126/science.ado5703.

OIST Research Updates: Memories of mitosis

 

53BP1-mediated activation of the tumor suppressor p53

Belal H, Ying Ng EF, Meitinger F.  

Current Opinion in Cell Biology 2024 Dec;91:102424. doi: 10.1016/j.ceb.2024.102424. Epub 2024 Sep 7.

 

2023

Methods of treating cancer with PLK4 inhibitors

Oegema, K, Shiau, AK, Desai, A, Meitinger, F, and Davis, RL.

US Patent 11,612,604

 

2021

TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity

Meitinger F*, Kong D*, Ohta M*, Desai A, Oegema K, Loncarek J.

Journal of Cell Biology. 2021 Jul 5;220(7):e202010180. doi: 10.1083/jcb.202010180. Epub 2021 May 13.

 

Promoter-proximal CTCF-binding Promotes Long-range-enhancer Dependent Gene Activation

Kubo N, Ishii H, Xiong X, Bianco S, Meitinger F, Hu R, Hocker JD, Conte M, Gorkin D, Yu M, Li B, Dixon JR, Hu M, Nicodemi M, Zhao H, Ren B.

Nat Struct Mol Biol. 2021 Feb;28(2):152-161. doi: 10.1038/s41594-020-00539-5. Epub 2021 Jan 4.

 

2020

The ubiquitin ligase TRIM37 controls cancer-specific vulnerability to PLK4 inhibition

Meitinger F#, Ohta M, Lee KY, Watanabe S, Davis RL, Anzola JV, Kabeche R, Jenkins DA, Shiau AK, Desai A#, Oegema K#.

Nature. 2020 Sep;585(7825):440-446. doi: 10.1038/s41586-020-2710-1. Epub 2020 Sep 9.

Highlighted in Nature Reviews Drug Discovery and Cancer Discovery.

 

Centriole-independent mitotic spindle assembly relies on the PCNT-CDK5RAP2 pericentriolar matrix

Watanabe S*, Meitinger F*, Shiau AK, Oegema K#, Desai A#.

Journal of Cell Biology. 2020 Dec 7;219(12):e202006010. doi: 10.1083/jcb.202006010.

 

2019

Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity

Gemble S, Simon A, Pennetier C, Dumont M, Hervé S, Meitinger F, Oegema K, Rodriguez R, Almouzni G, Fachinetti D, Basto R.

Current Biology. 2019 Sep 23;29(18):3072-3080.e5. doi: 10.1016/j.cub.2019.07.052. Epub 2019 Sep 5.

 

2018

NDF, a nucleosome-destabilizing factor that facilitates transcription through nucleosomes

Fei J, Ishii H, Hoeksema MA, Meitinger F, Kassavetis GA, Glass CK, Ren B, Kadonaga JT.

Genes & Development. 2018 May 1;32(9-10):682-694. doi: 10.1101/gad.313973.118. Epub 2018 May 14.

 

2017

Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates

Kim T, Lara-Gonzalez P, Prevo B, Meitinger F, Cheerambathur DK, Oegema K, Desai A.

Genes & Development. 2017 Jun 1;31(11):1089-1094. doi: 10.1101/gad.302067.117. Epub 2017 Jul 11.

 

The septin-associated kinase Gin4 recruits Gps1 to the site of cell division

Meitinger F, Pereira G.

Molecular Biology of the Cell. 2017 Apr 1;28(7):883-889. doi: 10.1091/mbc.E16-09-0687. Epub 2017 Feb 1.

 

2016

53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration

Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK, Oegema K.

Journal of Cell Biology 214, 155-166.

Highlighted and summarized in:

Soussi, T. and Kroemer, G. (2016) TP53 and 53BP1 Reunited. Trends in Cell Biology.

Strzyz, P. (2016) Cell Signalling to cell cycle arrest. Nature Reviews Molecular Cell Biology

Durocher, D. and Pelletier, L. (2016) 53BP1 Goes Back to its p53 Roots. Molecular Cell

Lambrus and B.G., Holland, A.J. (2017) A new mode of of mitotic Surveillance. Trends in Cell Biology

 

Actomyosin ring driven cytokinesis in budding yeast

Meitinger F#, Palani S#.

Semin Cell Dev Biol. 2016 May;53:19-27. doi: 10.1016/j.semcdb.2016.01.043. Epub 2016 Feb 1.

 

Detection of Phosphorylation Status of Cytokinetic Components

Meitinger F, Palani S, Pereira G.

Methods Mol Biol. 2016;1369:219-37. doi: 10.1007/978-1-4939-3145-3_16.

 

Visualization of Cytokinesis Events in Budding Yeast by Transmission Electron Microscopy

Meitinger F, Pereira G.

Methods Mol Biol. 2016;1369:87-95. doi: 10.1007/978-1-4939-3145-3_7.

 

2014

A memory system of negative polarity cues prevents replicative aging

Meitinger F, Khmelinskii A, Morlot S, Kurtulmus B, Palani S, Andres-Pons A, Hub B, Knop M, Charvin G, Pereira G.

Cell. 2014 Nov 20;159(5):1056-1069. doi: 10.1016/j.cell.2014.10.014. Epub 2014 Nov 13.

Highlighted in Wedlich-Söldner, R. (2014). A longer life for yeast with good memory. Dev. Cell, 31:391-392.

 

2013

A safeguard mechanism regulates Rho GTPases to coordinate cytokinesis with the establishment of cell polarity

Meitinger F, Richter H, Heisel S, Hub B, Seufert W, Pereira G.

PLoS Biology. 2013;11(2):e1001495. doi: 10.1371/journal.pbio.1001495. Epub 2013 Feb 26.

 

Dual function of the NDR-kinase Dbf2 in the regulation of the F-BAR protein Hof1 during cytokinesis

Meitinger F, Palani S, Hub B, Pereira G.

Mol Biol Cell. 2013 May;24(9):1290-304. doi: 10.1091/mbc.E12-08-0608. Epub 2013 Feb 27.

 

Lre1 directly inhibits the NDR/Lats kinase Cbk1 at the cell division site in a phosphorylation-dependent manner

Mancini Lombardi I, Palani S, Meitinger F, Darieva Z, Hofmann A, Sharrocks AD, Pereira G.

Current Biology. 2013 Sep 23;23(18):1736-45. doi: 10.1016/j.cub.2013.07.032. Epub 2013 Aug 15.

 

2012

The power of MEN in cytokinesis

Meitinger F, Palani S, Pereira G.

Cell Cycle. 2012 Jan 15;11(2):219-28. doi: 10.4161/cc.11.2.18857. Epub 2012 Jan 15.

 

Cdc14-dependent dephosphorylation of Inn1 contributes to Inn1-Cyk3 complex formation

Palani S, Meitinger F, Boehm ME, Lehmann WD, Pereira G.

Journal of Cell Science. 2012 Jul 1;125(Pt 13):3091-6. doi: 10.1242/jcs.106021. Epub 2012 Mar 27.

 

2011

Phosphorylation-dependent regulation of the F-BAR protein Hof1 during cytokinesis

Meitinger F, Boehm ME, Hofmann A, Hub B, Zentgraf H, Lehmann WD, Pereira G.

Genes & Development. 2011 Apr 15;25(8):875-88. doi: 10.1101/gad.622411.

 

2010

Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast

Meitinger F, Petrova B, Lombardi IM, Bertazzi DT, Hub B, Zentgraf H, Pereira G.

Journal of Cell Science. J Cell Sci. 2010 Jun 1;123(Pt 11):1851-61. doi: 10.1242/jcs.063891. Epub 2010 May 4.

Highlighted in Bradbury, J. (2010). Mitotic-exit networks with cytokinesis. J. Cell Sci. 123, 1103e.