RESEARCH

Centrioles are ancient cell organelles that localize at the core of centrosomes, playing essential roles in cell division and the formation of cilia and flagella. Centrioles have beautiful nine-fold symmetric structures that duplicate once per cell cycle in a process reminiscent of DNA replication.

Our lab seeks to uncover how centrioles have evolved to control such divergent functions and how they are faithfully inherited during sexual reproduction to maintain their critical roles. Defects in centriole structure or function can lead to genetic disorders such as microcephaly, infertility, and cancer. Through our research, we aim to shed light on the molecular mechanisms governing centriole biology, contributing to understanding the mechanisms underlying these diseases.