Dr.Kohgaku Eguchi

nrim Kohgaku Eguchi main

Kohgaku Eguchi

Group Leader & Senior Staff Scientist

Ph.D. in Information Technology, Kyushu Institute of Technology, Fukuoka, Japan
MSc in Information Technology, Kyushu Institute of Technology, Fukuoka, Japan
BSc in Information Technology, Kyushu Institute of Technology, Fukuoka, Japan

Email: kohgaku.eguchi@oist.jp

I am interested in the molecular mechanisms of synaptic function using electrophysiological and immunoelectron microscopic techniques, particularly focusing on the physiological role of phospholipid-protein interactions at synapses.

Professional Experience

  • Institute of Science and Technology Austria (Klosterneuburg, Austria), Postdoctoral fellow (PI: Ryuichi Shigemoto), 2017 - 2023
  • Okinawa Institute of Science and Technology Graduate University (Okinawa, Japan), Staff scientist (PI: Tomoyuki Takahashi), 2014 - 2017
  • Okinawa Institute of Science and Technology Graduate University (Okinawa, Japan), Postdoctoral Scholar (PI: Tomoyuki Takahashi), 2007 - 2014
  • Kyushu Institute of Technology (Fukuoka, Japan), Graduate researcher (PI: Kiyonori Yoshii), 2002 - 2007

Grants & Awards

  • Cellular Neurophysiology Editors’ Pick 2021, Frontiers in Cellular Neuroscience, 2021
  • Marie Skłodowska-Curie Individual Fellowship, European Commission, 2018 - 2020
  • Grant-in-Aid for Young Scientists (B), JSPS, Japan, 2015 - 2017
  • Grant-in-Aid for Young Scientists (B), JSPS, Japan, 2012 - 2014

Technical Skills

Patch-clamp recording (in vitro, brain slices), Transmission electron microscopy, SDS-digested freeze-fracture replica labeling (SDS-FRL), Ultra-thin section TEM, In Utero/vivo electroporation, Mouse peeled lingual epithelium preparation, programming (R, Python, C), conventional statistics, statistical modeling

Significant Publications

  1. Eguchi K.*, Le Monnier E., & Shigemoto R*. (2023). Nanoscale phosphoinositide distribution on cell membranes of mouse cerebellar neurons. The Journal of Neuroscience, in Press. *Corresponding authors
  2. Eguchi K.*, Velicky P., Hollergschwandtner E., Itakura M., Fukuzawa Y., Danzl JG. & Shigemoto R*. (2020). Advantages of Acute Brain Slices Prepared at Physiological Temperature in the Characterization of Synaptic Functions. Frontiers in Cellular Neuroscience, 14:63. *Corresponding authors, Cellular Neurophysiology Editors’ Pick 2021
  3. Eguchi K.*, Taoufiq Z., Thorn-Seshold O., Trauner D., Hasegawa M. & Takahashi T*. (2017). Wild-Type Monomeric α-Synuclein Can Impair Vesicle Endocytosis and Synaptic Fidelity via Tubulin Polymerization at the Calyx of Held. The Journal of Neuroscience, 37(25):6043-6052. *Corresponding authors
  4. Taoufiq Z.*, Eguchi K.*, & Takahashi T. (2013). Rho-Kinase Accelerates Synaptic Vesicle Endocytosis by Linking Cyclic GMP-Dependent Protein Kinase Activity to Phosphatidylinositol-4,5-Bisphosphate Synthesis. The Journal of Neuroscience, 33(29): 12099-12104. *Equally contributed authors
  5. Eguchi K.*, Nakanishi S., Takagi H., Taoufiq Z., Takahashi T*. (2012). Maturation of a PKG-Dependent Retrograde Mechanism for Exoendocytic Coupling of Synaptic Vesicles. Neuron, 74(3): 517–529. *Corresponding authors
  6. Eguchi K., Ohtubo Y., Yoshii K. (2008). Functional Expression of M3, a Muscarinic Acetylcholine Receptor Subtype, in Taste Bud Cells of Mouse Fungiform Papillae. Chemical Senses, 33(1): 47-55.