Biophysics of Cellular Membranes

Course Aim

This lecture series introduces the basic concepts and current research in cellular biophysics of biological membrane systems.
この講義では、生体膜系の細胞生物物理学について、基本概念および最近の研究について概説する。

Course Description

Explore concepts of biophysics including thermal conformational fluctuation and thermal diffusion, and consider how cells might take advantage of these physical processes to enable their functions. Discover how the cell membrane system functions in light of these physical processes to fulfil its critical contribution to cell signal transduction and metabolism. With extensive use of student presentations about topics of cellular signaling in the context of cellular cancer biology, immunology, and neurobiology, discuss the dynamic structures of the plasma membrane, including domain structures, tubulovesicular network, endocytosis and exocytosis, and cytoskeletal interactions. Learn methods of single-molecule imaging-tracking and manipulation for directly “seeing” the thermal, stochastic processes exhibited by receptors and downstream signaling molecules during signaling in live cells.

Course Contents

日程:
1. Basic concepts in immunology
免疫学の基本概念
2. Innate immunity
自然免疫
3. Antigen recognition by B-cell and T-cell receptors
B細胞T細胞受容体による抗原認識
4. The generation of lymphocyte antigen receptors
リンパ球の抗原受容体
5. Antigen presentation to T lymphocytes
T細胞への抗原提示
6. Signaling through immune system receptors
免疫システム受容体を介するシグナリング
7. The development and survival of lymphocytes
リンパ球の発生と生存
8. T cell-mediated immunity
T細胞を介した免疫
9. The humoral immune response
液性免疫反応
10. Dynamics of adaptive immunity
獲得免疫のダイナミクス
11. The mucosal immune system
粘膜免疫システム
12. Failures of host defense mechanism
生体防御機構の不全
13. Allergy and Hypersensitivity
アレルギーと過敏反応
14. Autoimmunity and Transplantation
自己免疫疾患と移植

Assessment

Report 50%; Final exam 50%

Prerequisites or Prior Knowledge

Biology, chemistry, and/or physics at undergraduate levels

Textbooks

Mary Luckey, Membrane Structural Biology 2nd Ed. Cambridge University Press

Reference Books

original papers will be supplied as required

Research Specialties