Extrasynaptic Excitations Extrasynaptic receptors are essential for producing activity in this striatal neuron. Neurons were recorded from brain tissue slices in three different conditions. In graph 1, the researchers electrically stimulated a neuron without any extrasynaptic response, or in a “down” state. In graph 2, the researchers added the neurotransmitter NMDA. This lifted the membrane potential, and made it possible to provoke many action potentials with electric stimulation. In graph 3, the researchers added memantine and showed that the drug blocks nearly all action potentials by blocking most extrasynaptic activity. Extrasynaptic receptors are essential for producing activity in this striatal neuron. Neurons were recorded from brain tissue slices in three different conditions. In graph 1, the researchers electrically stimulated a neuron without any extrasynaptic response, or in a “down” state. In graph 2, the researchers added the neurotransmitter NMDA. This lifted the membrane potential, and made it possible to provoke many action potentials with electric stimulation. In graph 3, the researchers added memantine and showed that the drug blocks nearly all action potentials by blocking most extrasynaptic activity. Date: 17 November 2014 Copyright OIST (Okinawa Institute of Science and Technology Graduate University, 沖縄科学技術大学院大学). Creative Commons Attribution 4.0 International License (CC BY 4.0). Download full-resolution image Tags Research Researchers Share on: Related Images X-ray micro-CT X-ray micro-CT 3D model of ant Burriel-Ha’s 3D model of the ant head and first segment next to the 3D image on the computer used to print it. Dr. Yuuri Yasuoka Dr. Yuuri Yasuoka Specialist operating the MRI instrument for small animals Specialist operating the MRI instrument for small animals. Training is a prerequisite for the use of the facility. The MRI instrument The head of an anesthetized animal is immobilized while the animal undergoes MRI imaging.
3D model of ant Burriel-Ha’s 3D model of the ant head and first segment next to the 3D image on the computer used to print it.
3D model of ant Burriel-Ha’s 3D model of the ant head and first segment next to the 3D image on the computer used to print it.
Specialist operating the MRI instrument for small animals Specialist operating the MRI instrument for small animals. Training is a prerequisite for the use of the facility.
Specialist operating the MRI instrument for small animals Specialist operating the MRI instrument for small animals. Training is a prerequisite for the use of the facility.
The MRI instrument The head of an anesthetized animal is immobilized while the animal undergoes MRI imaging.
The MRI instrument The head of an anesthetized animal is immobilized while the animal undergoes MRI imaging.