Effects of Topo II-Targeting Cancer Drugs

With DNA topoisomerase II (topo II) intact, DNA in fission yeast cells replicates normally and is split evenly between two daughter cells (left). When under the effects of anti-cancer drug ICRF-193, the DNA becomes tangled in the center of the parent cell, preventing its clean division.

With DNA topoisomerase II (topo II) intact, DNA in fission yeast cells replicates normally and is split evenly between two daughter cells (left). When under the effects of anti-cancer drug ICRF-193, the DNA becomes tangled in the center of the parent cell, preventing its clean division.

Date:
31 January 2019

Copyright OIST (Okinawa Institute of Science and Technology Graduate University, 沖縄科学技術大学院大学). Creative Commons Attribution 4.0 International License (CC BY 4.0).

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