The disruption of the JunB gene prevents T-Helper Rogue cells to become toxic.

1) The normal process in which JunB can activate the Interleukin 23 (IL23) receptor gene to make the T Helper 17 cell sensitive to Interleukin 23. This potentially lead to the T Helper 17 cell to turn toxic. 2) Knocking down JunB prevents the production of Interleukin-23 receptors, and the T-Helper 17 cell cannot turn rogue any longer, but is still able to fight infections.
Date:
30 May 2017
Copyright OIST (Okinawa Institute of Science and Technology Graduate University, 沖縄科学技術大学院大学). Creative Commons Attribution 4.0 International License (CC BY 4.0).
Tags
Research