The Stopwatch Complex forms during an extended mitosis

The Stopwatch Complex forms during an extended mitosis

During an extended mitosis PLK1 triggers the formation of a Mitotic Stopwatch Complex that stabilizes and activates the tumor suppressor p53. This complex accumulates during one or successive prolonged mitoses and ultimately causes cell arrest or cell death.

Date:
25 March 2024
Credit:
Meitinger et al., 2024
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