Connectivity map of a Multi-electrode Array (MEA) showing electrophysiological activity between the electrodes.
19 Jun 2015
The top half of the MEA housed the compartment containing cells from the mouse cortex.  The bottom half housed the compartment containing cells from the mouse striatum. When the axons reaching...
Type: Photo
OIST researchers who recreated a working corticostriatal network in culture
19 Jun 2015
Seated: From left to right, Marianela Garcia-Munoz, Professor Gordon Arbuthnott, Head of the Brain Mechanism for Behaviour Unit and Reuven Pnini.  Standing: From left to right, Eddy Taillefer,...
Type: Photo
19 Jun 2015
Mapping the human brain’s network of interconnections, known as the connectome is typically done with help from computational tools because recreating interconnections between different brain...
Type: News Article
Dr. Violeta Lopez-Huerta and Professor Gordon Arbuthnott of the OIST Brain Mechanism for Behaviour Unit
11 Mar 2015
First author Dr. Violeta Lopez-Huerta and Professor Gordon Arbuthnott of the OIST Brain Mechanism for Behaviour Unit in the lab where they mapped the neostriatum. 
Type: Photo
Panoramic view of a mouse brain including the neostriatum.
11 Mar 2015
The virus stains in red the connections leaving the neostriatum wherever it is expressed, but not everywhere as was expected.  In the engineered mouse strain the neurons were already fluorescent...
Type: Photo
17 Nov 2014
Synapse, the name for the signal-receiving site on a neuron, comes from the Greek word for contact. Neuroscientists used to maintain that neurons form one-to-one relationship to contact one another....
Type: News Article
17 Nov 2014
The neurons in this video contain a dye that fluoresces when it encounters calcium ions. When the neuron is excited, calcium floods into the cell and the neuron fluoresces. The researchers monitored...
Type: Video
Extrasynaptic Excitations
17 Nov 2014
Extrasynaptic receptors are essential for producing activity in this striatal neuron. Neurons were recorded from brain tissue slices in three different conditions. In graph 1, the researchers...
Type: Photo
Extrasynapse Researchers
17 Nov 2014
Marianela Garcia-Munoz (left) and Violeta Lopez-Huerta (right) work in the Brain Mechanism for Behavior Unit, led by Professor Gordon Arbuthnott (center), where they recently completed a study on...
Type: Photo
2 May 2013
As a PhD student at the University of Aberdeen in the UK, Gordon Arbuthnott came across a paper by a group in Sweden that introduced him the world of the dopamine, a neurotransmitter commonly dubbed...
Type: News Article
Dopamine Pathways
2 May 2013
In the brain, dopamine helps regulate reward and body movement. As part of the reward pathway, dopamine is produced by neurons in the ventral tegmental area (VTA) and released in the nucleus...
Type: Photo
Spiny Neurons Receive Dopamine
2 May 2013
The dendrite branches of spiny neurons are littered with spines, or receptor sites, for neurotransmitters, including dopamine. Spiny neurons play a crucial role in initiating and regulating movements...
Type: Photo
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