[Seminar] Flows and Topological Changes During Tissue Morphogenesis

[Seminar] Flows and Topological Changes During Tissue Morphogenesis
Monday April 8th, 2024 03:00 PM to 04:00 PM
OIST Lab1 B503 Seminar Room

Description

Seminar title: Flows and Topological Changes During Tissue Morphogenesis

Speaker: Professor Luiza Angheluta-Bauer, Condensed Matter Physics, University of Oslo

Hosted by Professor Mahesh Bandi Nonlinear and Non-equilibrium Physics Unit

Abstract:

Collective structural arrangements and cell migration are important physical processes underlying tissue development and regeneration. Understanding the complexity of cell-cell interactions and the emergence of collective behaviors at the tissue scale presents formidable challenges both experimentally and theoretically.

In this talk, I will discuss recent theoretical work on the dynamical patterns that emerge at the tissue scale from localized rearrangements and topological defects. Using a multi-phase field model, we demonstrate that tissue fluidity stems from cell neighbor exchanges, serving as transient sources of vortical flow. This flow emerges from the relative dispersion of cells at a rate proportional to the frequency of rearrangements. Balancing collective migration with relative cell motion appears to be essential for maintaining tissue shape and fluidity. Using a cell-based model, we study the tissue's response to the presence of a vortex. While solid-like behavior tends toward conical shapes, localized fluidization triggers the transition to a tube, which is fundamental in biological tissues.

Zoom information:

https://oist.zoom.us/j/93408109638?pwd=QitldllLeCtnbXBIZnlTNVVvWTZBUT09

Meeting ID: 934 0810 9638   Passcode: 378549

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