csu FY2019 Annual Report 3.2 Figure 6
Figure 6. Schematic representation of the role of CNOT3 in NSCLC cells. CNOT3, one key subunit of the CCR4-NOT complex, is highly expressed in NSCLC cells and is required for the proper expression of some other subunits including CNOT1, CNOT2, CNOT7, and CNOT9. CNOT3 regulates the expression of p21 through mRNA degradation. CNOT3 also specifically degrades the mRNA of KLF2, which regulates the expression of p21 through transcription. When CNOT3 is depleted in NSCLC cells, the expression levels of KLF2 and p21 are elevated, resulting in the impairment of cell proliferation.
Date:
04 March 2024
Copyright OIST (Okinawa Institute of Science and Technology Graduate University, 沖縄科学技術大学院大学). Creative Commons Attribution 4.0 International License (CC BY 4.0).
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