g0 FY2018 Annual Report Figure 4
![g0 FY2018 Annual Report Figure 4](/sites/default/files/styles/embed_lg_1x/public/2024-02/g0_WithWithoutTopo.png?itok=E9iKx9WQ)
Figure 4. Casein kinase II (CKII) phosphorylates DNA topoisomerase II (topo II), thus activating the ATPase domain of the enzyme (left). This activation cancels the effects of anti-cancer drug ICRF-193. If CKII activity is attenuated (right), the efficacy of ICRF-193 is rescued. The G0 Cell Unit demonstrated this mechanism in fission yeast, a simple model that could be used for anti-cancer drug screening.
Date:
28 February 2024
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