FY2019 Annual Report

Genomics and Regulatory Systems Unit
Professor Nicholas M. Luscombe

Abstract

1. Staff

  • Nicholas M. Luscombe, Professor (Adjunct)
  • Charles Plessy, Staff Scientist
  • Jai A. Denton, Researcher
  • Zhe Chen, Researcher
  • Mariana Velasque, Researcher
  • Michael J. Mansfield, Research Scientist
  • Andrew W. Liu, Senior Technician
  • Aki Masunaga, Technician
  • Yongkai Tan, Technician
  • Aleksandra Bliznina, Graduate Student
  • Yuka Ozaki, Research Unit Administrator

2. Collaborations

3. Activities and Findings

4. Publications

4.1 Journals

  1. Garth R. Ilsley, Ritsuko Suyama, Takeshi Noda, Nori Satoh & Nicholas M. Luscombe. Finding cell-specific expression patterns in the early Ciona embryo with single-cell RNA-seq. Scientific Reports, doi:10.1038/s41598-020-61591-1(2020)
  2. Cai Li, Nicholas M Luscombe. Nucleosome Positioning Stability Is a Modulator of Germline Mutation Rate Variation Across the Human Genome. Nature Communications, doi:10.1038/s41467-020-15185-0 (2020)
  3. Alessandro Bonetti, Federico Agostini, Ana Maria Suzuki, Kosuke Hashimoto, Giovanni Pascarella, Juliette Gimenez, Leonie Roos, Alex J. Nash, Marco Ghilotti, Christopher J.  F. Cameron, Matthew Valentine, Yulia A. Medvedeva, Shuhei Noguchi, Eneritz Agirre, Kaori Kashi, Samudyata, Joachim Luginbühl, Riccardo Cazzoli, Saumya Agrawal, Nicholas M. Luscombe, Mathieu Blanchette, Takeya Kasukawa, Michiel de Hoon, Erik Arner, Boris Lenhard, Charles Plessy, Gonçalo Castelo-Branco, Valerio Orlando & Piero Carninci RADICL-seq identifies general and cell type–specific principles of genome-wide RNA-chromatin interactions. Nature Communications, doi:10.1038/s41467-020-14337-6 (2020)
  4. Stéphane Poulain, Ophélie Arnaud, Sachi Kato, Iris Chen, Hiro Ishida, Piero Carninci, Charles Plessy. Machine-driven Parameter Screen of Biochemical Reactions. Nucleic Acids Research, doi: 10.1093/nar/gkaa079 (2020)
  5. X. Du‐Harpur, F.M. Watt, N.M. Luscombe, M.D. Lynch. What is AI? Applications of artificial intelligence to dermatology. British Journal of Dermatology,doi:10.1111/bjd.18880 (2020)
  6. Giulia E Tyzack, Raphaelle Luisier, Doaa M Taha, Jacob Neeves, Miha Modic, Jamie S Mitchell, Ione Meyer, Linda Greensmith, Jia Newcombe, Jernej Ule, Nicholas M Luscombe, Rickie Patani. Widespread FUS Mislocalization Is a Molecular Hallmark of Amyotrophic Lateral Sclerosis. Brain : a Journal of Neurology, doi:10.1093/brain/awz217 (2019)
  7. Michael Briese, Nejc Haberman, Christopher R Sibley, Rupert Faraway, Andrea S Elser, Anob M Chakrabarti, Zhen Wang, Julian König, David Perera, Vihandha O Wickramasinghe, Ashok R Venkitaraman, Nicholas M Luscombe, Luciano Saieva, Livio Pellizzoni, Christopher W J Smith, Tomaž Curk, Jernej Ule. A Systems View of Spliceosomal Assembly and Branchpoints With iCLIP. Nature Structural & Molecular Biology, doi: 10.1038/s41594-019-0300-4 (2019)
  8. Julien Pichon, Nicholas M. Luscombe, Charles Plessy. Widespread use of the “ascidian” mitochondrial genetic code in tunicates. F1000Research, doi: 10.12688/f1000research.21551.1.(2019)

4.2 Books and other one-time publications

Nothing to report

4.3 Oral and Poster Presentations

  1. Plessy C. Title: Oikopleura Dioica: the Animal Genome Pushed to Its Limits, Marine Science Day, Okinawa, September 24th, 2019
  2. Plessy C. Title: The zooplankton Oikopleura dioica from the point of view of systems biology, The International Conference on Systems Biology (ICSB 2019), Okinawa, November 4th, 2019
  3. Kumar S. Poster Title: Classication of Pluripotent genes using Machine Learning Techniques, The International Conference on Systems Biology (ICSB 2019), Okinawa, November 1st-4th, 2019

5. Intellectual Property Rights and Other Specific Achievements

Nothing to report

6. Meetings and Events

6.1 Seminar

  • Date: June 8, 2019
  • Venue: OIST Campus Lab3
  • Speaker: Dr. Ferenc Mueller (University of Birmingham)

7. Other

Nothing to report.