csu FY2021 Annual Report 3.2 Figure 2
Figure 2: Early lymphocyte development regulated by the CCR4-NOT complex. The CCR4-NOT complex is required for differentiation of pro-B cells to pre-B cells and positive selection of DP thymocytes. ZFP36L1 and ZFP36L2 (ZFP36L1/2) regulate the pro-B cell to pre-B cell transition and b-selection of the DN3 thymocyte stage. Involvement of the CCR4-NOT complex in b selection has not been verified yet. Some differentiation stages were omitted for simplicity. CLP, common lymphoid progenitor; DN, CD4 CD8 double negative thymocyte; DP, CD4 CD8 double positive thymocyte; SP, CD4 or CD8 single positive thymocytes.
Copyright OIST (Okinawa Institute of Science and Technology Graduate University, 沖縄科学技術大学院大学). Creative Commons Attribution 4.0 International License (CC BY 4.0).
