Abstract: Our internal organs are often moving during their normal functions: hearts beat, lungs expand, and bladders fill. The mechanical forces generated by these movements are actively detected by the nervous system to drive physiology. Force detection in mammals is accomplished through mechanosensory PIEZO ion channels, which are critical for several internal sensory processes, including baroreception and the detection of bladder filling.  We use PIEZO ion channels as molecular handles to understand how mechanosensory information is detected, and how it influences important physiological processes in the urinary and gastrointestinal tracts.  

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