Research Units

The Algorithms for Ecological and Evolutionary Genomics Unit develops computer algorithms for core problems in genomics to study the genomes of every extant species on our planet.

The mission of the Analysis and PDE unit is to reveal and analyze the mathematical principles reflecting natural phenomena expressed by partial differential equations and advance the boundar...

Analysis on Metric Spaces Unit explores analytic and geometric problems arising in diverse spaces, especially those with no priori smooth structures. Our research focuses on partial diff...

The Applied Cryptography Unit investigates the design and analysis of modern cryptographic primitives and schemes used to protect the confidentiality and integrity of data – at rest, being communicated or computed upon – both in the classical and the quantum settings. Particular areas of interest include the design and analysis of quantum / post-quantum cryptography schemes, the algebraic cryptanalysis of symmetric and asymmetric key algorithms, as well as the design and analysis of primitives for privacy-preserving cryptographic mechanisms.

Our group focuses on unveiling lots of mysteries surrounding astrophysical explosive phenomena such as supernovae (SNe) and gamma-ray bursts (GRBs). SNe and GRBs are the most powerful explosions in the universe, yet very little is known about their explosion mechanisms. These astrophysical big bangs fascinate us with their unknown physics and puzzling astronomical phenomena such as gravitational waves, neutrinos, nucleosynthesis, non-equilibrium ionization, ultra-high-energy cosmic rays. Through our theoretical and computational approaches, we strive to reveal the complete pictures of these explosions and provide the-state-of-the-art physical interpretations for current, cutting-edge observations and useful predictions for future observations by next-generation astronomical observatories.

The Biodiversity and Biocomplexity Unit explores how ecological and evolutionary processes generate and sustain biodiversity, and how those processes are being altered by human activities.

The Biological Complexity Unit studies how biophysical systems, ranging from subcellular circuits to cellular populations, can function despite being subject to random fluctuations.

The Biological Design Unit investigates what determines biological forms by untangling the evolution of structural functions and organismal development in the changing climate.

The biological nonlinear dynamics data science unit investigates complex systems explicitly taking into account the role of time. We do this by instead of averaging occurrences using their statistics, we treat observations as frames of a movie and if patterns reoccur then we can use their behaviors in the past to predict their future. In most cases the systems that we study are part of complex networks of interactions and cover multiple scales. These include but are not limited to systems neuroscience, gene expression, posttranscriptional regulatory processes, to ecology, but also include societal and economic systems that have complex interdependencies. The processes that we are most interested in are those where the data has a particular geometry known as low dimensional manifolds. These are geometrical objects generated from embeddings of data that allows us to predict their future behaviors, investigate causal relationships, find if a system is becoming unstable, find early warning signs of critical transitions or catastrophes and more. Our computational approaches are based on tools that have their origin in the generalized Takens theorem, and are collectively known as empirical dynamic modeling (EDM). As a lab we are both a wet and dry lab where we design wet lab experiments that maximize the capabilities of our mathematical methods. The results from this data driven science approach then allows us to generate mechanistic hypotheses that can be again tested experimentally for empirical confirmation. This approach merges traditional hypothesis driven science and the more modern Data driven science approaches into a single virtuous cycle of discovery.

We seek the principles governing the behavior of whole organisms, integrating physics, biology and computational approaches to understand life's most complex and fascinating phenomena.

The Biological Systems Unit is working on devices in which microorganisms break down waste, releasing energy in the process. Key Okinawan industries such as awamori distilleries, pig and chi...

The Cell Division Dynamics Unit studies the mechanisms of chromosome segregation and cell fate determination during mitosis with a focus on mitotic spindle assembly and positioning in cultured human cells and Medaka embryos.

Every day, millions of cells divide to sustain essential tissue functions. Errors in this process can lead to developmental disorders or cancer. Our research focuses on the molecular mechanisms of cell division and quality control in both normal and cancer cells, aiming to uncover how cells maintain genomic stability and regulate proliferation. By integrating high-throughput imaging, gene editing, and genome-wide screening, we seek to expand our understanding of these fundamental processes and how their dysregulation contributes to cancer. Our lab is driven by a curiosity-based approach, grounded in the belief that fundamental research is essential for uncovering the principles that govern life. By investigating the intricate mechanisms controlling cell division, genome maintenance, and cellular quality control, we aim to reveal how these processes go awry in cancer. Through this knowledge, we strive to identify cancer-specific vulnerabilities, discover novel biomarkers, and open new avenues for targeted therapeutic strategies.

Using a mouse model, the Cell Signal Unit explores the cause of various diseases that include cancer, neuronal disorders, immunological diseases, and diabetes/obesity at the molecular level....

The Chemistry and Chemical Bioengineering Unit develops methods and strategies for the construction of organic molecules that contribute to biomedical research and drug discovery.

The Cognitive Neurorobotics Research Unit is dedicated to investigating the principles of embodied cognition by conducting experimental studies in synthetic neurorobotics. The primary goals of our research are to understand:on how innate structures can be leveraged to develop cognitive constructs through iterative but limited behavioral experiences; how primary intersubjectivity in social cognition can be formed through enactive and contextual interactions with others; and how subjective experiences such as consciousness and free will can be scientifically and phenomenologically explained. In addition, our developmental neurorobotics approach is intended to uncover the underlying mechanisms of neurodevelopmental disorders, such as schizophrenia and autism. Through these researches, we can expect to deepen our ontological understanding of human beings, rather than simply creating another smart machine-learning robot.

Collective Dynamics and Quantum Transport Unit explores dynamical and transport phenomena in various quantum matters and their spintronic, electronic, and quantum-information applications.

We study multiscale and multiphysics problems related to fluid dynamics by numerical simulations. Our research is focused on turbulence, non-Newtonian fluids and multiphase flows.